Urolithin A with Cas 1143-70-0
What is Urolithin A?
Urolithin A (UA), a natural metabolite, is generated by intestinal microorganisms during the digestion of ellagic acid and its derivatives. Pomegranate, strawberry, raspberry, walnut, and other foods constitute its primary dietary sources.
In recent years, research has found that urolith A has multiple functions, including promoting muscle cell growth and metabolism, reducing oxidative stress, alleviating inflammation, and has been proven to be beneficial for improving human health, with positive effects on cellular health, especially for the health of the elderly.
It exhibits significant potential in improving Alzheimer’s disease, enhancing musculoskeletal health, anti-inflammatory and antioxidant effects, and weight management by activating mitochondrial autophagy, clearing damaged organelles, inhibiting inflammatory pathways, reducing β – amyloid deposition, and excessive phosphorylation of Tau protein.
Character:
(1) High purity: Urolithin A can be obtained as a high-purity product through natural extraction and refined manufacturing processes. High purity means better bioavailability and fewer adverse reactions.
(2) Safety: Urolithin A is a natural product that has been proven to be safe for the human body.
(3) Stability: Urolithin A has good stability and can maintain its activity and effectiveness under different environments and storage conditions.
Runtai chemical is a professional and reliable China manufacturer of Urolithin A (UA), with higher purity and lower price for 15 years. If you interest our Urolithin A (UA) , feel free to contact us for free sample!
Recommended
Dosage: (exact dosage should be subject to customer’s finial product formulation.)
Urolithin A Quick details
- Chemical Name:Urolithin A
- CAS No.: 1143-70-0
- EINECS: 1592732-453-0
- Molecular Fomula: C13H8O4
- Molecular weight:228..2
- Appearance:Beige to yellow powder
- Assay: 98%min
- Synonyms:3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one;3,8-DIHYDROXYDIBENZO-(B,D)PYRAN-6-ONE;3,8-Dihydroxy-6H-benzo[c]chromen-6-one;CaChemicalbookstoreumpigmentI;UrolithinA;6H-Dibenzo(B,D)pyran-6-one,3,8-dihydroxy-;3,8-dihydroxy-6H-dibenzopyran-6-one);urolithin-A(UA
Urolithin A Typical Properties
| Item | Specification | Results |
| Appearance | Beige to yellow powder | Conform |
| Identification | 1HNMR confirms to structure | Conform |
| LCMS | LCMS Conforms to MW | Conform |
| Water | ≤0.5% | 0.23% |
| Purity (HPLC) | ≥98.0% | 99.86% |
| Heavy metals | ||
| Pb | ≤0.5ppm | <0.5ppm |
| As | ≤1.5ppm | <1.5ppm |
| Cd | ≤0.5ppm | <0.5ppm |
| Hg | ≤0.1ppm | <0.1ppm |
| Residual solvents | ||
| Methanol | ≤3000ppm | 90ppm |
| TBME | ≤1000ppm | Not detected |
| Toluene | ≤890ppm | Not detected |
| DMSO | ≤5000ppm | 20ppm |
| Acetic Acid | ≤5000ppm | 110ppm |
| Conclusion | The results conforms with enterprise standards | |
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Urolithin A Applications
Support for NAD+ Natural Recycle
Supplementation with urolithin A can increase NAD+ levels in the body with mice experiencing an approximate 50% elevation in NAD+ levels. UA supplementation was comparable to the effect obtained by supplementing nicotinamide riboside, precursor of NAD, at a five-fold higher dose. Moreover, Urolithin A can increase NAD levels while reducing uric acid levels.
Circadian Modulation for Sleep Facilitation
Urolithin A can affect the expression rhythm of clock genes in intestinal epithelial cells, including expression level, amplitude, and peak phase. This regulation controls the timing of various physiological activities, ensuring that processes such as sleep, digestion and metabolism are aligned with the circadian cycle.
Promote Skin Whitening and Wound Repair
UA can reduce 45% melanin production in melanoma cells by inhibiting tyrosinase activity, and the effect is equivalent to that of 5μM kojic acid (positive control). UA can also promote the blood vessels rapidly formed within the wound, and the deposition and remodeling of collagen matrix were accelerated. UA group’s wounds exhibited the significantly higher intensity of collagen I and III deposition than control, and by day 21, the UA group’s wounds were almost completely closed.
Reduce Helicobacter & Strengthen Intestinal Barrier
AS a postbiotics, UA can effectively restrain the proliferation of Helicobacter pylori (Hp) and its adhesion to cells, thereby diminishing gastrointestinal damage caused by Hp. And UA can promotes the expression of MUC2 protein, enhancing the thickness of the colonic mucus layer, reducing mucosal permeability and consequently strengthening intestinal barrier function.
Urolithin A with Cas 1143-70-0 Package & Storage
- Package: 1kg/bag;25kg/drum
- Storage: Store in a cool place and keep it sealed to avoid direct sunlight.
